TYPES OF PEPTIDES

Please note that before any scheduled appointment(s) for peptide treatment begin, you are required to be medically evaluated by one of our practitioners at the Grossgold Clinic. This evaluation can be completed the day of your appointment(s). Remember, if you have any medical conditions that are contraindicated to receive peptide therapy, your treatment may be cancelled.

For more information on peptides, particularly the updates to therapeutics, click here to access a document regarding growth hormone and therapeutics from Wells™ Pharmacy Network.

ADVANCED THERAPY

GHRHS & GHRPS

(ADVANCED PEPTIDE THERAPY)

GHRHS ARE GROWTH HORMONE PULSE AMPLIFIERS

Sermorelin
Modified GRF (1-29) (CJC 1295 Without DAC)

  Action of GHRH is counteracted by somatostatin (prevents GH release).
  GHRHs increase levels of GH and IGF-1 – they act back on hypothalmus to stimulate somatostatin – for BALANCED HORMONE PRODUCTION.
  GHRHs stimulate pituitary to produce and release GH into bloodstream.

GHRHS ARE PLEOTROPIC

(capable of producing more than one benefit / effect)

  Assist In Wound Healing
  Cardio Protective
  Effects Are Systemic
  Have Direct Effect On Cells
  Immune System Function
  Involved In Glucose Homeostasis
  Significant Down Regulation Of Inflammatory Response

GHRPS ARE GROWTH HORMONE PULSE INITIATORS

Ipamorelin
GHRP 2, GHRP 6 (Not Currently Available Per FDA Regulation)

  All peptides obtained from the same precursor of ghrelin amino acid chain.
  GHRPs are ‘ghrelin mimics’.
  GHRPs are very receptor sensitive to dosing!
  GHRPs stimulate GH release at higher, more youthful pulse frequency / levels.

– Overdosing decreases GH production by desensitizing receptors.

Estrogen HRT facilitates GHRP action synergistically; GHRP effects shown to be potentiated by HRT in post-menopausal women.

IPAMORELIN

(ADVANCED PEPTIDE THERAPY)

Ipamorelin is a growth hormone releasing peptide (GHRP). Ipamorelin increases the release and stimulation of growth hormone (GH) from the anterior pituitary and suppresses somatostatin. GHRPs increase release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons, which diminishes due to oxidative damage as the body ages.

GHRPs are growth hormone initiators, stimulating GH release in pulses at higher, more youthful levels.

Growth hormone is released in pulses at regular intervals over 24-hour cycles. Pulse strength is highest during puberty and decreases by 15% per decade starting at age 30, resulting in typical signs of aging – cognitive decline, fat gain, lean muscle loss, poor sleep patterns, reduced bone density, and skin laxity.

Ipamorelin therapy can help increase mental clarity and vitality and improve many of the unwanted health issues associated with aging. It has demonstrated good safety and tolerability in human clinical studies.

POTENTIAL BENEFITS OF IPAMORELIN THERAPY

  Development Of Lean Muscle Mass
  Improved Libido
  Improved Sleep
  Increased Bone Density
  Increased Cognitive Acuity
  Increased Energy
  Reduced Adipose Deposits
  Strengthened Cardiovascular System

COMBINATION FORMULAS

GHRP combined with a growth hormone releasing hormone works synergistically to increase the frequency and strength of pulses, simulating natural, youthful hormone rhythms.

IPAMORELIN + GRF (1-29) (CJC 1295 WITHOUT DAC)

This formula combines Ipamorelin with Modified GRF (1-29) (growth hormone releasing hormone).

IPAMORELIN / SERMORELIN

This formula combines Ipamorelin with Sermorelin (growth hormone releasing hormone).

IPAMORELIN + MODIFIED GRF (1-29)

(ADVANCED PEPTIDE THERAPY)

Ipamorelin
Modified GRF (1-29) (CJC 1295 Without DAC)

Human growth hormone is naturally produced in the pituitary gland and plays a vital role in cell regeneration, growth, and maintaining healthy human tissue, including that of the brain and various vital organs. The pituitary releases growth hormone in pulses at regular intervals over 24-hour cycles. The frequency and strength of these pulses is highest at around age 20 and then begins to decline, decreasing by 15% per decade starting at age 30. This slowdown can lead to elevated cholesterol levels, low libido, poor sleep, reduced bone density, sluggish metabolism, the loss of lean muscle mass, and weight gain.

Ipamorelin is a growth hormone releasing peptide (GHRP). GHRPs naturally stimulate the body to increase the pulse frequency of growth hormone release, similar to when the body was younger. GHRPs increase the release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons. The secretory capacity becomes diminished due to oxidative damage as we age. Ipamorelin does not stimulate the appetite like the peptide, GHRP 6, has demonstrated good safety and tolerability in human clinical studies, and increases nitrogen retention. Ipamorelin does not create cortisol or prolactin and even at higher doses has been shown to stimulate a large release of growth hormone without receptor desensitization.

Modified GRF (1-29) (CJC 1295 Without DAC) is a growth hormone releasing hormone (GHRH). In the body, GHRH is produced in the hypothalamus. The principal function of GHRH is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. This then acts on virtually every tissue of the body to control various physical functions and processes. GHRHs stimulate the pituitary to amplify or increase the strength of the growth hormone pulses. Modified GRF (1-29) acts upon receptors located in the anterior pituitary gland and signals the pituitary gland to increase the amount of growth hormone released per pulse.

Ipamorelin + Modified GRF (1-29) work together synergistically. The goal of administering them after combining the two on a daily basis is to stimulate the patient’s body to increase both the frequency and strength of growth hormone pulses, thereby creating a more effective, natural, and youthful cycle of growth hormone release. Ipamorelin’s half-life is approximately two hours, and Modified GRF (1-29) has a half-life of approximately 30 minutes. The short half-life of this combination product is considered more natural as it stimulates a strong pulse of human growth hormone that is more similar to the body’s natural release patterns.

Advanced peptide therapy with Ipamorelin + Modified GRF (1-29) can help increase mental clarity and vitality and improve many of the unwanted health issues associated with aging.

POTENTIAL BENEFITS OF IPAMORELIN + MODIFIED GRF (1-29) THERAPY

  Better Memory
  Improved Mental Functions
  Improved Recovery After Workouts
  Improved Sleep Patterns
  Increased Bone Density
  Increased Energy
  Increased Endurance
  Increased Lean Muscle Mass
  Increased Libido
  Increased Vitality