TYPES OF PEPTIDES
ADVANCED THERAPY
GHRHS & GHRPS
(ADVANCED PEPTIDE THERAPY)
GHRHS ARE GROWTH HORMONE PULSE AMPLIFIERS:
Sermorelin
Modified GRF (1-29) (CJC 1295 WITHOUT DAC)
Action of GHRH is counteracted by somatostatin (prevents GH release).
GHRHs increase levels of GH and IGF-1 – they act back on hypothalmus to stimulate somatostatin – for BALANCED HORMONE PRODUCTION.
GHRHs stimulate pituitary to produce and release GH into bloodstream.
GHRHS ARE PLEOTROPIC:
(capable of producing more than one benefit / effect)
Assist in wound healing.
Cardio protective.
Effects are systemic.
Have direct effect on cells.
Immune system function.
Involved in glucose homeostasis.
Significant down regulation of inflammatory response.
GHRPS ARE GROWTH HORMONE PULSE INITIATORS:
Ipamorelin
GHRP 2, GHRP 6 (Not Currently Available Per FDA Regulation)
All peptides obtained from the same precursor of ghrelin amino acid chain.
GHRPs are “ghrelin mimics”.
GHRPs are very receptor sensitive to dosing!
GHRPs stimulate GH release at higher, more youthful pulse frequency / levels.
– Overdosing decreases GH production by desensitizing receptors.
Estrogen HRT facilitates GHRP action synergistically; GHRP effects shown to be potentiated by HRT in post-menopausal women.
IPAMORELIN
(ADVANCED PEPTIDE THERAPY)
Ipamorelin is a growth hormone releasing peptide (GHRP). Ipamorelin increases the release and stimulation of growth hormone (GH) from the anterior pituitary and suppresses somatostatin. GHRPs increase release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons, which diminishes due to oxidative damage as the body ages.
GHRPs are growth hormone initiators, stimulating GH release in pulses at higher, more youthful levels.
Growth hormone is released in pulses at regular intervals over 24 hour cycles. Pulse strength is highest during puberty and decreases by 15% per decade starting at age 30, resulting in typical signs of aging – cognitive decline, fat gain, lean muscle loss, poor sleep patterns, reduced bone density, and skin laxity.
Ipamorelin therapy can help increase mental clarity and vitality and improve many of the unwanted health issues associated with aging. It has demonstrated good safety and tolerability in human clinical studies.
POTENTIAL BENEFITS OF IPAMORELIN THERAPY:
Development of lean muscle mass.
Improved libido.
Improved sleep.
Increased bone density.
Increased cognitive acuity and energy.
Reduced adipose deposits.
Strengthened cardiovascular system.
COMBINATION FORMULAS:
GHRP combined with a growth hormone releasing hormone works synergistically to increase the frequency and strength of pulses, simulating natural, youthful hormone rhythms.
IPAMORELIN + GRF (1-29) (CJC 1295 WITHOUT DAC)
This formula combines Ipamorelin with Modified GRF (1-29) (growth hormone releasing hormone).
IPAMORELIN / SERMORELIN
This formula combines Ipamorelin with Sermorelin (growth hormone releasing hormone).
IPAMORELIN + MODIFIED GRF (1-29)
(ADVANCED PEPTIDE THERAPY)
Ipamorelin
Modified GRF (1-29) (CJC 1295 WITHOUT DAC)
Human growth hormone is naturally produced in the pituitary gland and plays a vital role in cell regeneration, growth, and maintaining healthy human tissue, including that of the brain and various vital organs. The pituitary releases growth hormone in pulses at regular intervals over 24 hour cycles. The frequency and strength of these pulses is highest at around age 20 and then begins to decline, decreasing by 15% per decade starting at age 30. This slowdown can lead to elevated cholesterol levels, low libido, poor sleep, reduced bone density, sluggish metabolism, the loss of lean muscle mass, and weight gain.
Ipamorelin is a growth hormone releasing peptide (GHRP). GHRPs naturally stimulate the body to increase the pulse frequency of growth hormone release, similar to when the body was younger. GHRPs increase the release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons. The secretory capacity becomes diminished due to oxidative damage as we age. Ipamorelin does not stimulate the appetite like the peptide, GHRP 6, has demonstrated good safety and tolerability in human clinical studies, and increases nitrogen retention. Ipamorelin does not create cortisol or prolactin and even at higher doses has been shown to stimulate a large release of growth hormone without receptor desensitization.
Modified GRF (1-29) (CJC 1295 WITHOUT DAC) is a growth hormone releasing hormone (GHRH). In the body, GHRH is produced in the hypothalamus. The principal function of GHRH is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. This then acts on virtually every tissue of the body to control various physical functions and processes. GHRHs stimulate the pituitary to amplify or increase the strength of the growth hormone pulses. Modified GRF (1-29) acts upon receptors located in the anterior pituitary gland, and signals the pituitary gland to increase the amount of growth hormone released per pulse.
Ipamorelin + Modified GRF (1-29) work together synergistically. The goal of administering them after combining the two on a daily basis is to stimulate the patient’s body to increase both the frequency and strength of growth hormone pulses, thereby creating a more effective, natural, and youthful cycle of growth hormone release. Ipamorelin’s half-life is approximately two hours, and Modified GRF (1-29) has a half-life of approximately 30 minutes. The short half-life of this combination product is considered more natural as it stimulates a strong pulse of human growth hormone that is more similar to the body’s natural release patterns.
Advanced peptide therapy with Ipamorelin + Modified GRF (1-29) can help increase mental clarity and vitality and improve many of the unwanted health issues associated with aging.
POTENTIAL BENEFITS OF IPAMORELIN + MODIFIED GRF (1-29) THERAPY:
Better memory and improved mental functions.
Improved recovery after workouts.
Improved sleep patterns.
Increased bone density.
Increased endurance, energy, and vitality.
Increased lean muscle mass.
Increased libido.
Reduced body fat.
Strengthened cardiovascular system.
Strengthened immune system.
ANTI-AGING THERAPY
EPITHALON
(ANTI-AGING PEPTIDE THERAPY)
Epithalon is a synthetically-derived tetrapeptide whose sequence of amino acids is Alanine-Glutamate-Asparagine-Glycine. Epithalon was originally developed by Russian scientist Vladimir Khavinson, who conducted over three decades of extensive animal and human clinical research trials on the efficacy and safety of this peptide.
Epithalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, the protective parts of DNA.
Younger people produce relatively large amounts of telomerase and therefore, longer telomeres. The longer the telomere strands are, the better cell health and replication function they provide. As people age, the production of telomerase falls and telomeres become shorter, resulting in declining cell health and replication.
Epithalon’s ability to increase the production of telomerase lengthens and strengthens telomeres, meaning it can play a vital role in decreasing the aging process and thus, improving general health and quality of life.
POTENTIAL BENEFITS OF EPITHALON THERAPY:
Decreasing the aging process.
Delaying and preventing the onset of age-related diseases such as cancer, cardiovascular disease, and dementia.
Healing of deteriorating and injured muscle cells.
Improved appearance and skin health.
Promotion of deeper sleep.
Significantly boosted energy levels.
IPAMORELIN
(ANTI-AGING PEPTIDE THERAPY)
As part of the natural aging process, your body produces less and less of its own natural hormones over time. This slowdown can lead to elevated cholesterol levels, low libido, poor sleep, reduced bone density, sluggish metabolism, the loss of lean muscle mass, and weight gain.
Many of these symptoms of aging may be relieved and even reversed with advanced peptide therapy and hormone optimization.
Ipamorelin therapy can help improve many of the unwanted health problems associated with aging and increase mental clarity and vitality.
POTENTIAL BENEFITS OF IPAMORELIN THERAPY:
Better memory and improved mental functions.
Improved sleep patterns.
Increased bone density.
Increased endurance, energy, and vitality.
Increased lean muscle mass, reduced body fat.
Increased libido.
Strengthened cardiovascular system.
Strengthened immune system.
These benefits increase even more when you add exercise to your program.
Ipamorelin is a growth hormone releasing peptide (GHRP) that stimulates the body to release its own natural growth hormone at more youthful levels.
GHRPs improve the immune system by reducing the body’s inflammation response. Since inflammation plays a role in many chronic diseases, reducing inflammation is one of the keys to disease prevention.
IPAMORELIN + GRF (1-29) (CJC 1295 WITHOUT DAC)
This formula combines Ipamorelin with Modified GRF (1-29) (growth hormone releasing hormone). This combination works synergistically to increase the frequency your body releases growth hormone, simulating natural, youthful hormone rhythms.
SERMORELIN
(GHRH FOR ANTI-AGING THERAPY)
Human aging is accompanied by declining growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels. Growth hormone is required for bone development, normal growth, and regulatory effects on carbohydrate, lipid, and protein metabolism.
Sermorelin is a growth hormone releasing hormone (GHRH) that stimulates the patient’s own pituitary gland by binding to specific receptors to increase production and secretion of GH. Sermorelin does not bypass the pituitary-GH axis, therefore allowing control of IGF-1 fluctuating levels as needed to preserve optimal health.
Sermorelin and other GHRHs promote slow-wave sleep (Stage III) by increasing GH release at night – the most important of the cycles of growth hormone release.
POTENTIAL BENEFITS OF SEMORELIN THERAPY:
Better memory and improved mental functions.
Improved sleep patterns.
Increased bone density.
Increased endurance, energy, and vitality.
Increased lean muscle mass, reduced body fat.
Increased libido.
Strengthened cardiovascular system.
Strengthened immune system.
COMBINATION FORMULAS:
GHRH combined with a growth hormone releasing peptide works synergistically to increase the frequency and strength of pulses, simulating natural, youthful hormone release rhythms.
IPAMORELIN / SERMORELIN
This formula combines Ipamorelin (growth hormone releasing peptide) with Sermorelin.
GROWTH HORMONES
GROWTH HORMONE, PEPTIDE THERAPY, & THE AGING PROCESS
Growth hormone releasing hormone (GHRH) is produced in the hypothalamus. Its principal function is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. This then acts on virtually every tissue in the body to control various physical functions and processes. Insulin-like growth factor-1 (IGF-1) is produced in the liver and other organs in response to growth hormone, which in turn acts in many tissues to cause growth and metabolic actions. In addition to its effect on growth hormone secretion, GHRH also affects food intake, memory, and sleep.
The action of GHRH on the pituitary gland is counteracted by somatostatin, a hormone also produced by the hypothalamus, which prevents growth hormone release. In order to maintain a balanced hormone production, GH, GHRH, IGF-1, and somatostatin levels are regulated by one another.
Growth hormone levels plateau in young adult life and then decline progressively, accompanied by an increase in abdominal fat, and a loss of aerobic capacity and muscle mass.
After the third decade of life, there is a progressive decline of growth hormone secretion, decreasing by approximately 15% every decade. Secretion peaks at puberty, then decreases to approximately one-sixth of that amount by age 55.
Growth hormone releasing peptides (GHRPs) stimulate growth hormone release in pulses at more youthful levels. This helps increase cognitive acuity and energy, reduce adipose deposits, and stimulate development of lean muscle mass. All peptides are obtained from the same precursor of ghrelin 27-28 amino acid chain.
GHRPs increase the release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons. The secretory capacity becomes diminished due to oxidative damage as we age. GHRPs improve the function of the thymus, increasing its size and restoring the aged, shrunken organ to a more youthful state.
GHRPs are growth hormone pulse initiators, while GHRHs are growth hormone pulse amplifiers. A combination of GHRH with GHRP works synergistically, increasing the frequency and strength of pulses to create a more effective, youthful cycle of growth hormone release.
Both men and women who are experiencing age-related symptoms of hormonal changes can benefit from peptide therapy, and through pharmaceutical compounding, these therapies can be tailored to each patient’s unique needs.
POTENTIAL BENEFITS OF GROWTH HORMONE THERAPY:
Improved cognitive abilities.
Improved sleep patterns.
Increased bone density and calcium retention.
Increased endurance and strength.
Increased lean muscle mass, reduced body fat.
Increased libido.
Strengthened connective tissue and joints.
Strengthened immune system.
POPULAR PEPTIDE FORMULATIONS:
Ipamorelin
Ipamorelin + Modified GRF (1-29) (CJC 1295 WITHOUT DAC)
Ipamorelin + Sermorelin
Ipamorelin Sublingual
Sermorelin
Sermorelin Sublingual
IBUTAMOREN (MK-677)
(GROWTH HORMONE SECRETAGOGUE)
Ibutamoren (MK-677) is a growth hormone secretagogue and a long-acting, selective agonist of the ghrelin receptor. It mimics the growth hormone stimulating action of the hormone, ghrelin. Ibutamoren has been shown to increase the secretion of several hormones, including GH and IGF-1, and produces sustained increased levels of these hormones without affecting cortisol levels.
The increased production of growth hormone allows the body to rejuvenate and repair itself over time, slowing down the aging process. Both GH and IGF-1 stimulate an increase in muscle mass and strength, and a reduction of body fat.
Ibutamoren is orally administered, which makes it unique from other secretagogues, and it remains active in the body for a longer period of time compared to injectable secretagogues, GHRP 2 or GHRP 6. Ibutamoren remains active in the body for roughly 24 hours and requires only a once daily dose at bedtime (GH levels remain elevated for about 90 minutes after administering a GHRP 2 or GHRP 6 injection).
One clinical study showed that Ibutamoren can be more effective the longer it is taken. The study measured IGF-1 levels in the blood, which is an indirect measure of growth hormone levels. The study results showed the following increases in IGF-1 levels:
At two weeks, subjects had an increase of 30% in IGF-1 levels.
At six months, subjects had an increase of 60% in IGF-1 levels.
At 12 months, subjects had an increase of 72% in IGF-1 levels.
Like some of its injectable secretagogue cousins, Ibutamoren also causes an increase in the hormone, ghrelin, that stimulates hunger. The hunger side effect can be minimized by taking Ibutamoren at bedtime or with a large meal. Although Ibutamoren can cause an increase in hunger, Ibutamoren use typically increases calorie deposition into the muscle instead of fat due to the accompanying increase of GH.
Ibutamoren can also help promote better sleep cycles. It has been shown to increase the amount of time spent in REM sleep by 20% and Stage Four deep sleep by 50%. The more time spent in deep sleep, the more recovery and repair the body can accomplish. REM sleep also plays an important role in cognitive functioning and overall mental health and wellbeing.
Other health benefits of increasing growth hormone levels include decreased body fat, increased bone density, increased energy, increased lean muscle, increased strength, and lower cholesterol.
The most frequent side effects were an increase in appetite that subsided within a few months and mild, transient lower extremity edema and muscle pain.
HEALING
BPC-157
(THE HEALING PEPTIDE)
BPC-157 (Body Protective Compound) is a pentadecapeptide. This biologically active peptide fragment is derived from human gastric juice. It has been demonstrated to promote the healing of previously acquired injuries and protect the body from injury.
BPC-157 is highly stable and resistant to both enzyme digestion and hydrolysis. It can be given orally, but can also be administered intramuscularly or subcutaneously – no carrier molecule is required.
BPC-157 HAS NO SIDE EFFECTS, NO TOXICITY!
Better Healing, Faster Healing!
BPC-157 decreases inflammatory response, increases angiogenesis, and promotes muscle and tendon healing. It has excellent potential for diabetic wound healing and produces more Type One collagen. BPC-157 also repairs bones, brain tissue, teeth, the cornea, and the intestines.
BPC-157 works to correct both acute and chronic conditions in the body. It is systemic in action, but can also be administered directly to the site of the injury (joint, muscle, tendon). BPC-157 prevents scar tissue buildup after injury and reduces existing scar tissue. The healing time of injuries is greatly decreased with the administration of BPC-157. BPC-157 can counteract the effects of steroid use to achieve normal healing of muscle tissue.
BPC-157 Does Not Affect Receptors – It’s All About The Signaling!
This peptide has significant anti-inflammatory modulating effects. BPC-157 promotes tissue healing through signaling pathways – it provides a specific response to a particular injury through cell signaling. BPC-157 upregulates gene transcription to influence these healing factors.
BPC-157 CREATES HOMEOSTASIS TO STRESS RESPONSE!
BCP-157 is in clinical trials for inflammatory bowel disease (IBD). This peptide is also cytoprotective – it counteracts NSAID lesions in the GI tract, so it can help get patients off of proton pump inhibitors (PPIs). BCP-157 protects against hepatoxicity and can even counteract it.
BPC-157 HAS MULTIPLE SITES OF ACTION!
It counteracts the side effects of Parkinson’s agents, improves nerve regeneration, and induces the release of seratonin in the nigrostriatal area of the brain. BPC-157 can be used continuously as a body protective, or for a specific period to treat body injuries.
THYMOSIN BETA-4
(UNIQUE HEALING PEPTIDE)
Thymosin Beta-4 is a small, 43 amino acid peptide. It is found in all cell types, except red blood cells, and in all tissues. The unique potential of this peptide as a healing substance lies in that it interacts with cellular actin and regulates its activity.
Thymosin Beta-4 has other regenerative effects for healing and repair of damaged tissue. It down-regulates cytokines, is a chemo-attractant for cells, reduces inflammation, thus protecting newly formed tissue from damaging inflammatory events, and stimulates new blood vessel growth. Studies have shown it has the ability to repair wounds using its anti-inflammatory characteristics. It does not bind to extracellular matrixes and has a very low molecular weight, which allows it the potential to migrate long distances within tissues to locate areas of injury for repair.
POTENTIAL BENEFITS OF THYMOSIN BETA-4 THERAPY:
Allowing connective tissue to stretch.
Improved intercellular substance exchanges.
Improved muscle tone.
Increased endurance and muscle growth.
Preventing the formation of adhesions and fibrous bands on ligaments, muscles, and tendons.
Promotion of tissue repair.
Reduced cramps and muscle spasms.
Reduced joint tissue inflammation.
Other user-reported beneficial effects include darkening of gray hair, improved flexibility, and re-growth of hair. The healing properties of this peptide have been noted in bones, eyes, ligaments, muscles, skin, and tendons.
