TYPES OF PEPTIDES

ADVANCED THERAPY

GHRHS AND GHRPS

(ADVANCED PEPTIDE THERAPY)

GHRHs are growth hormone pulse Amplifiers:

Sermorelin
GRF 1-29 modified (CJC 1295 w/o DAC)

  GHRHs stimulates pituitary to produce & release GH into bloodstream
  Action of GHRH is counteracted by somatostatin (prevents GH release)
  GHRH increases levels of GH and IGF-1 – they act back on hypothalmus to stimulate somatostatin – for BALANCED HORMONE PRODUCTION

GHRHs are pleotropic

(capable of producing more than one effect/benefit)

  Have direct effect on cells
  Effects are systemic
  Significant down regulation of inflammatory response
  Cardio protective
  Assist in wound healing
  Immune system function
  Involved in glucose homeostasis

GHRPs are growth hormone pulse Initiators:

Ipamorelin
GHRP 2, GHRP 6 (not currently available per FDA regulation)

  GHRPs are ‘ghrelin mimics’
  GHRPs stimulate GH release at higher, more youthful pulse levels/frequency
  All peptides obtained from the same precursor of ghrelin amino acid chain
  GHRPs are very receptor sensitive to dosing!

– Overdosing decreases GH production by desensitizing receptors

Estrogen HRT facilitates GHRP action synergistically; GHRP effects shown to
be potentiated by HRT in post-menopausal women.

IPAMORELIN

(ADVANCED PEPTIDE THERAPY)

Ipamorelin is a Growth Hormone Releasing Peptide (GHRP). Ipamorelin suppresses somatostatin and increases the stimulation and release of Growth Hormone (GH) from the anterior pituitary. GHRPs increase release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons, which diminishes due to oxidative damage as the body ages.

GHRPs are Growth Hormone INITIATORS, stimulating GH release in pulses at higher, more youthful levels.

Growth hormone is released in pulses at regular intervals over 24 hour cycles. Pulse strength is highest during puberty and decreases by 15% per decade starting at age 30, resulting in typical signs of aging – lean muscle loss, fat gain, skin laxity, cognitive decline, poor sleep patterns, reduced bone density.

Ipamorelin therapy can help increase vitality and mental clarity and improve many of the unwanted health issues associated with aging. It has demonstrated good safety and tolerability in human clinical studies.

Potential benefits of Ipamorelin therapy:

  Development of lean muscle mass
  Reduced adipose deposits
  Increased bone density
  Improved sleep
  Increased energy and cognitive acuity
  Strengthened cardiovascular system
  Improved libido

AVAILABLE IN THESE STRENGTHS:

Ipamorelin 9mg, 15mg

Combination Formulas:

GHRP combined with a Growth Hormone Releasing Hormone works synergistically to increase the frequency and strength of pulses, simulating natural, youthful hormone rhythms.

Ipamorelin+GRF 1-29 (CJC 1295 w/o DAC) 9mg/5mg

This formula combines Ipamorelin with modified GRF 1-29 (growth hormone releasing hormone).

Ipamorelin 15mg/Sermorelin 15mg

This formula combines Ipamorelin with Sermorelin (growth hormone releasing hormone).

IPAMORELIN+MODIFIED GRF 1-29

(ADVANCED PEPTIDE THERAPY)

Ipamorelin+GRF 1-29 (CJC 1295 w/o DAC) 9mg/5mg

Human growth hormone is naturally produced in the pituitary gland and plays a vital role in cell regeneration, growth and maintaining healthy human tissue, including that of the brain and various vital organs. The pituitary releases growth hormone in pulses at regular intervals over 24 hour cycles. The strength and frequency of these pulses is highest at around age 20 and then begins to decline, decreasing by 15% per decade starting at age 30. This slowdown can lead to poor sleep, elevated cholesterol levels, sluggish metabolism, low libido, the loss of lean muscle mass, reduced bone density and weight gain.

Ipamorelin is a growth hormone releasing peptide (GHRP). GHRPs naturally stimulate the body to increase the pulse frequency of growth hormone release, similar to when the body was younger. GHRPs increase the release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons. The secretory capacity becomes diminished due to oxidative damage as we age. Ipamorelin increases nitrogen retention, has demonstrated good safety and tolerability in human clinical studies, and does not stimulate the appetite like the peptide GHRP-6. Ipamorelin does not create prolactin or cortisol and even at higher doses has been shown to stimulate a large release of growth hormone without receptor desensitization.

Modified GRF 1-29 (CJC 1295 without DAC) is a growth hormone releasing hormone (GHRH). In the body, GHRH is produced in the hypothalamus. The principal function of GHRH is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. This then acts on virtually every tissue of the body to control various physical functions and processes. GHRHs stimulate the pituitary to increase or amplify the strength of the growth hormone pulses. Mod GRF 1-29 acts upon receptors located in the anterior pituitary gland, and signals the pituitary gland to increase the amount of growth hormone released per pulse.

Ipamorelin+Modified GRF 1-29 work together synergistically. The goal of combining the two and administering them on a daily basis is to stimulate the patient’s body to increase both the strength and frequency of growth hormone pulses, thereby creating a more youthful, natural and effective cycle of growth hormone release. MODIFIED GRF 1-29 has a half-life of approximately 30 mins, and Ipamorelin’s half-life is approximately 2 hrs. The short half-life of this combination product is considered more natural as it stimulates a strong pulse of human growth hormone that is more similar to the body’s natural release patterns.

Advanced peptide therapy with Ipamorelin+Modified GRF 1-29 can help increase vitality and mental clarity and improve many of the unwanted health issues associated with aging.

Benefits include:

  Reduced body fat
  Increased lean muscle mass
  Increased bone density
  Strengthened immune system
  Increased libido
  Increased energy, endurance, and vitality
  Improved recovery after workouts
  Strengthened cardiovascular system
  Improved sleep patterns
  Improved mental functions and better memory

ANTI-AGING THERAPY

EPITHALON

(ANTI-AGING PEPTIDE THERAPY)

Epithalon is a synthetically-derived tetrapeptide whose sequence of amino acids is Alanine-Glutamate-Asparagine-Glycine. Epithalon was originally developed by Russian scientist Vladimir Khavinson, who conducted over three decades of extensive animal and human clinical research trials on the safety and efficacy of this peptide.

Epitalon’s primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, the protective parts of DNA.

Younger people produce relatively large amounts of telomerase and therefore longer telomeres. The longer the telomere strands are, the better cell health and replication function they provide. As people age, the production of telomerase falls and telomeres become shorter, resulting in declining cell replication and health.

Epithalon’s ability to increase the production of telomerase strengthens and lengthens telomeres, meaning it can play a vital role in decreasing the aging process and thus improving general health and quality of life.

Potential Benefits of Epithalon

  Significant boosting of energy levels
  Promotion of deeper sleep
  Delay and prevent onset of age-related diseases such as cancer, cardiovascular disease and dementia
  Improvement of skin health and appearance
  Healing of injured and deteriorating muscle cells
  Decrease the aging process

IPAMORELIN

(ANTI-AGING PEPTIDE THERAPY)

As part of the natural aging process, your body produces less and less of its own natural hormones over time. This slowdown can lead to poor sleep, elevated cholesterol levels, sluggish metabolism, low libido, the loss of lean muscle mass, reduced bone density and weight gain.

Many of these symptoms of aging may be relieved and even reversed with hormone optimization and advanced peptide therapy.

Ipamorelin therapy can help increase vitality and mental clarity and improve many of the unwanted health problems associated with aging.

Benefits include:

  Reduced body fat, increased lean muscle mass
  Increased bone density
  Strengthened immune system
  Increased libido
  Increased energy, endurance, and vitality
  Strengthened cardiovascular system
  Improved sleep patterns
  Improved mental functions and better memory

These benefits increase even more when you add exercise to your program.

Ipamorelin is a Growth Hormone Releasing Peptide (GHRP) that stimulates the body to release its own natural growth hormone at more youthful levels.

GHRPs improve the immune system by reducing the body’s inflammation response. Since inflammation plays a role in many chronic diseases, reducing inflammation is one of the keys to disease prevention.

Ipamorelin+GRF 1-29 (CJC 1295 w/o DAC)

This formula combines Ipamorelin with GRF 1-29 (growth hormone releasing hormone). This combination works synergistically to increase the frequency your body releases growth hormone, simulating natural, youthful hormone rhythms.

SERMORELIN

(GHRH FOR ANTI-AGING THERAPY)

Human aging is accompanied by declining growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels. Growth Hormone is required for normal growth, bone development and regulatory effects on protein, carbohydrate and lipid metabolism.

Sermorelin is a growth hormone-releasing hormone (GHRH) that stimulates the patient’s own pituitary gland by binding to specific receptors to increase production and secretion of GH. Sermorelin does not bypass the pituitary-GH axis, therefore allowing control of IGF-1 fluctuating levels as needed to preserve optimal health.

Sermorelin and other GHRHs promote slow wave sleep (stage III) by increasing GH release at night – the most important of the cycles of growth hormone release.

Potential benefits of Semorelin therapy:

  Reduced body fat, increased lean muscle mass
  Increased bone density
  Strengthened immune system
  Increased libido
  Increased energy, endurance, and vitality
  Strengthened cardiovascular system
  Improved sleep patterns
  Improved mental functions and better memory

AVAILABLE IN THESE STRENGTHS:

Sermorelin 9mg, 15mg

Combination Formula:

GHRH combined with a Growth Hormone Releasing Peptide works synergistically to increase the frequency and strength of pulses, simulating natural, youthful hormone release rhythms.

Ipamorelin 15mg/Sermorelin 15mg

This formula combines Sermorelin with the growth hormone releasing peptide Ipamorelin.

GROWTH HORMONES

GROWTH HORMONE, THE AGING PROCESS, AND PEPTIDE THERAPY

Growth hormone-releasing hormone (GHRH) is produced in the hypothalamus. Its principal function is to stimulate the pituitary gland to produce and release growth hormone into the bloodstream. This then acts on virtually every tissue in the body to control various physical functions and processes. Insulin-like growth factor 1 (IGF-1) is produced in the liver and other organs in response to growth hormone, which in turn acts in many tissues to cause metabolic and growth actions. In addition to its effect on growth hormone secretion, GHRH also affects sleep, food intake and memory.

The action of GHRH on the pituitary gland is counteracted by somatostatin, a hormone also produced by the hypothalamus, which prevents growth hormone release. In order to maintain a balanced hormone production, GHRH, somatostatin, GH and IGF-1 levels are regulated by one another.

Growth Hormone levels plateau in young adult life and then decline progressively, accompanied by a loss of muscle mass and aerobic capacity, and an increase in abdominal fat.

After the third decade of life, there is a progressive decline of Growth Hormone secretion, decreasing by approximately 15% every decade. Secretion peaks at puberty (about 150 mcg/kg day) then decreases (to approx.25 mcg/kg/day) by age 55.

Growth Hormone Releasing Peptides (GHRPs) stimulate growth hormone release in pulses at more youthful levels. This helps stimulate development of lean muscle mass, reduce adipose deposits, and increases energy and cognitive acuity. All peptides are obtained from the same precursor of ghrelin 27-28 amino acid chain.

GHRPs increase the release of hypothalamic GHRH in part by helping to overcome the diminished secretory capacity of the release neurons. The secretory capacity becomes diminished due to oxidative damage as we age. GHRPs improve the function of the thymus, increasing its size and restoring shrunken, aged thymus to a more youthful state.

GHRPs are growth hormone pulse Initiators, while GHRHs are growth hormone pulse Amplifiers. A combination of GHRP with GHRH works synergistically, increasing the frequency and strength of pulses to create a more youthful, effective cycle of growth hormone release.

Both men and women who are experiencing age-related symptoms of hormonal changes can benefit from peptide therapy, and through pharmaceutical compounding these therapies can be tailored to each patient’s unique needs.

BENEFITS OF THIS THERAPY CAN INCLUDE:

  Reduction of fat, increase in lean muscle mass
  Strengthened immune system
  Improved sleep patterns
  Strengthening of joints and connective tissue
  Increase in bone density & increased calcium retention
  Improvement of cognitive abilities
  Increased strength and endurance
  Increased libido

SOME POPULAR PEPTIDE THERAPY FORMULATIONS:

  Sermorelin – 9mg, 15mg
  Sermorelin sublingual
  Sermorelin + Ipamorelin (15mg/15mg)
  Ipamorelin – 9mg, 15mg
  Ipamorelin sublingual
  Ipamorelin + mod GRF 1-29 (CJC1295 w/o DAC) – 9mg/5mg

IBUTAMOREN (MK-677)

(GROWTH HORMONE SECRETAGOGUE)

Ibutamoren (also known as MK-677) is a long-acting, selective agonist of the ghrelin receptor and a growth hormone secretagogue. It mimics the growth hormone stimulating action of the hormone ghrelin. Ibutamoren has been shown to increase the secretion of several hormones including GH and IGF-1 and produces sustained increased levels of these hormones without affecting cortisol levels.

The increased production GH allows the body to repair and rejuvenate itself over time, slowing down the aging process. Both growth hormone and IGF-1 stimulate an increase in muscle mass, muscle strength, and a reduction of body fat.

Ibutamoren is orally administered, which makes it unique from other secretagogues and it remains active in the body for a longer period of time compared to injectable secretagogues, GHRP 2 or GHRP 6. Ibutamoren requires only a once daily dose at bedtime and remains active for roughly 24 hours in the body (GH levels remain elevated for about 90 minutes after administering a GHRP 2 or GHRP 6 injection).

One clinical study showed that Ibutamoren can be more effective the longer it is taken. The study measured IGF-1 levels in the blood, which is an indirect measure of growth hormone levels. The study results showed the following increases in IGF-1 levels:

  At 2 weeks, subjects had an increase of 30% in IGF-1 levels
  At 6 months, subjects had an increase of 60% in IGF-1 levels
  At 12 months, subjects had an increase of 72% in IGF-1 levels

Like some of its injectable secretagouge cousins, Ibutamoren also causes an increase in the hormone ghrelin that stimulates hunger. The hunger side effect can be minimized by taking Ibutamoren at bedtime, or with a large meal. Although ibutamoren can cause an increase in hunger, typically Ibutamoren use increases calorie deposition into the muscle instead of fat due to the accompanying increase of GH.

Ibutamoren can also help promote better sleep cycles. It has been shown to increase the amount of time spent in Stage 4 deep sleep by 50%, and REM sleep by 20%. The more time spent in the deep sleep the more recovery and repair the body can accomplish. REM sleep also plays an important role in cognitive functioning and overall mental health and wellbeing.

Other health benefits of increasing growth hormone levels include increased bone density, increased energy, lower cholesterol, increased strength, increased lean muscle and decreased body fat.

The most frequent side effects were an increase in appetite that subsided within a few months and transient, mild lower extremity edema and muscle pain.

HEALING

BPC-157

(THE HEALING PEPTIDE)

BPC-157 (Body Protective Compound) is a pentadecapeptide. This biologically active peptide fragment is derived from human gastric juice and has been demonstrated to protect the body from injury, as well promote healing of previously acquired injuries.

BPC-157 is highly stable, resistant to both hydrolysis and enzyme digestion. It can be given orally as well as administered subcutaneously or intramuscularly – no carrier molecule is required.

BPC-157 has NO TOXICITY, NO SIDE EFFECTS!

Better Healing, Faster Healing!

BPC-157 promotes muscle and tendon healing, increases angiogenesis and decreases inflammatory response. Produces more type 1 collagen and has excellent potential for diabetic wound healing. BPC-157 also repairs intestine, bone, teeth, brain tissue and the cornea.

BPC-157 works to correct both acute and chronic conditions in the body. It is systemic in action, but can also be administered directly to site of injury (tendon, muscle, joint). BPC-157 prevents scar tissue buildup after injury, and reduces existing scar tissue. Healing time of injuries is greatly decreased with the administration of BPC-157. BPC 157 can counteract the effects of steroid use to achieve normal healing of muscle tissue.

BPC-157 does not affect receptors – it’s all about the signaling!

This peptide has significant anti-inflammatory modulating effects. BPC-157 promotes tissue healing through signaling pathways – it provides specific response to particular injury thru cell signaling. BPC-157 up regulates gene transcription to influence these healing factors.

BPC-157 CREATES HOMEOSTASIS TO STRESS RESPONSE

BCP 157 is in clinical trials for IBD. Cytoprotective – it counteracts NSAID lesions in the GI tract, so it can help get patients off PPIs. Protects against hepatoxicity and can even counteract it.

BPC-157 HAS MULTIPLE SITES OF ACTION:

It improves nerve regeneration, induces release of seratonin in nigrostriatal area of brain, counteracts side effects of Parkinsons agents. BPC-157 can be used continuously as body protective, or for specific period to treat body injury.

THYMOSIN BETA-4

(UNIQUE HEALING PEPTIDE)

Thymosin beta 4 is a small 43 amino acid peptide. It is found in all tissues and in all cell types, except red blood cells. The unique potential of this peptide as a healing substance lies in that it interacts with cellular actin and regulates its activity.

Thymosin beta 4 has other regenerative effects for healing and repair of damaged tissue. It is a chemo-attractant for cells, stimulates new blood vessel growth, down-regulates cytokines and reduces inflammation, thus protecting newly formed tissue from damaging inflammatory events. Studies have shown it has the ability to repair wounds using its anti-inflammatory characteristics. It does not bind to extracellular matrixes and has a very low molecular weight, which allows it the potential to migrate long distances within tissues to locate areas of injury for repair.

Some of the potential benefits include:

  Promotes tissue repair
  Allows connective tissue to stretch
  Reduces joint tissue inflammation
  Prevents formation of adhesions and fibrous bands on ligaments, muscles and tendons
  Improvement of muscle tone
  Increased endurance, increased muscle growth
  Reduction of muscle spasms, cramps
  Improved intercellular substance exchanges

Other user-reported beneficial effects include improved flexibility, darkening of gray hair and re-growth of hair. The healing properties of this peptide have been noted in eyes, muscle, skin, bones, tendons and ligaments.

IMPORTANT! All information presented in this website is intended for informational purposes only and not for the purpose of rendering medical advice. Statements made on this website have not been evaluated by the Food and Drug Administration. The information contained herein is not intended to diagnose, treat, cure or prevent any disease.